A suspicious case of malignant hyperthermia during general anesthesia with desflurane: A case report

Cho, Yong Sung; Kim, Jun Hyun; Kim, Kyung Woo; Lee, Sang Il; Kim, Ji Yeon; Kim, Kyung Tae; Choe, Won Joo; Park, Jang Su; Kim, Jung Won

Case Report

Anesthetic Pharmacology

Anesthesia and Pain Medicine 2013;8(3):171-174.
Published online July 30, 2013.

A suspicious case of malignant hyperthermia during general anesthesia with desflurane: A case report

Yong Sung Cho, Jun Hyun Kim, Kyung Woo Kim, Sang Il Lee, Ji Yeon Kim, Kyung Tae Kim, Won Joo Choe, Jang Su Park, Jung Won Kim

Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea. ishmael@freechal.com

Abstract

Malignant hyperthermia (MH) is an inherited disorder of skeletal muscle manifested as a life threatening hypermetabolic crisis in susceptible individuals following exposure to commonly used inhaled anesthetics and depolarizing muscle relaxants. We experienced a suspicious case of MH in 34-year-old male during transfemoral cerebral angiography embolization under general anesthesia with desflurane. The episode emerged 15 minutes after induction of general anesthesia using propofol, rocuronium, remifentanil, desflurane. Desflurane is a recently developed inhaled anesthetics and there has been no case report of MH related with it in Korea. When we suspected episode, vigorous treatment was carried out, symptoms were resolved without dantrolene administration.

Key Words: Dantrolene, Desflurane, Fresh gas flow, Malignant hyperthermia