Association of 5-HT3A receptor Pro16Ser polymorphism with the incidence of PONV and the response to ondansetron in Korean patients

Goo, Eui Kyoung; Hwang, Jung Won; Song, Eun; So, Yun Mi; Ryu, Junghee; Jeon, Young Tae; Do, Sang Hwan; Jang, In Jin

Clinical Research

Anesthetic Pharmacology

Anesthesia and Pain Medicine 2008;3(4):255-259.
Published online October 30, 2008.

Association of 5-HT3A receptor Pro16Ser polymorphism with the incidence of PONV and the response to ondansetron in Korean patients

Eui Kyoung Goo, Jung Won Hwang, Eun Song, Yun Mi So, Junghee Ryu, Young Tae Jeon, Sang Hwan Do, In Jin Jang

¹Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. jungwon@snubh.org
²Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea.
³Clinical Pharmacology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Postopertative nausea and vomiting (PONV) are frequent and distressing side effects of surgery. Even though many drugs has been developed, PONV still remains unsolved problem. Ondansetron is a commonly used 5-HT3 receptor antagonist. It acts through specific binding to the 5-HT3A, 5-HT3B receptor complex. We hypothesized that patients with genetic variation in 5-HT3A receptor might have variable incidence of PONV and respond differently to ondansetron. METHODS: We included 204 patients undergoing gynecologic laparoscopic surgery. PONV were documented during 24 hours after operation. Ondansetron was injected to every patient who had PONV at PACU and PONV reassessed after 15 minutes. DNA was extracted from blood and 5-HT3A Pro16Ser missense mutation was analyzed by using real-time PCR. RESULTS: The incidence of PONV were 50% for wild type, 53% for heterozygote and 0% for homozygote. There were no significant differences between wild type and heterozygote in VAS of nausea and VAS change after ondansetron. CONCLUSIONS: 5-HT3A receptor Pro16Ser polymorphism is not associated with the incidence of PONV and the response to ondansetron in Korean patients.

Key Words: 5-HT3A receptor, ondansetron, polymorphism, PONV, Pro16Ser