Anesth Pain Med Search

CLOSE


Anesthetic Pharmacology
Anesthesia and Pain Medicine 2009;4(3):235-241.
Published online July 31, 2009.
Seventy-two hour peri-operative volume replacement with 6% HES 130/0.4 vs. 20% albumin in patients undergoing abdominal, cranial, and orthopedic surgery
Dong Hee Kim
Department of Anesthesiology and Pain Medicine, College of Medicine, Dankook University, Cheonan, Korea. ybs90@unitel.co.kr
Abstract
BACKGROUND
This study was designed to compare hydroxyethylstarch (HES) to albumin in high-risk surgery patients infused over 72 h peri-operatively; hemodynamic changes, oxygen transport parameters, blood gases, blood coagulation, blood loss, blood use, outcome, and costs were compared.
METHODS
High-risk surgical patients undergoing high-risk abdominal, cranial, and orthopaedic surgery were treated with 6% HES (130/0.4; n = 41) or 20% albumin (n = 19).The goal of volume therapy was to maintain a normal cardiac index (CI; 3.0 L/min/m2) over 72 h peri-operatively.
RESULTS
The hemodynamic and cardiac effects of 6% HES were superior to 20% albumin.HES reduced disturbances in blood coagulation, blood loss, and blood use as compared to albumin. Volume therapy with HES and albumin improved patient outcomes.Use of HES resulted in a significant cost reduction compared to albumin.
CONCLUSIONS
Volume replacement with 6% HES and 20% albumin in surgery over 72 h peri-operatively improved hemodynamic parameters and oxygen transport to normal values.HES provides a cost-effective alternative to albumin in surgery with improved efficacy and safety.
Key Words: albumin, cardiac index, high risk surgery, hydroxyethylstarch, volume replacement
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 1,254 View
  • 8 Download
Related articles in Anesth Pain Med


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: apm@anesthesia.or.kr                

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next