The optimal concentrations of propofol at eye opening and orientation after propofol-remifentanil TCI in Koreans

Im, Kyong Shil; Kim, Jong Bun; Lee, Jae Myeong; Jung, Hyun ju; Han, Sang Woo; Kim, Dae Woo; Ryu, Keon Hee

Clinical Research

Anesthetic Pharmacology

Anesthesia and Pain Medicine 2011;6(2):131-137.
Published online April 30, 2011.

The optimal concentrations of propofol at eye opening and orientation after propofol-remifentanil TCI in Koreans

Kyong Shil Im, Jong Bun Kim, Jae Myeong Lee, Hyun ju Jung, Sang Woo Han, Dae Woo Kim, Keon Hee Ryu

Department of Anesthesiology and Pain Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea. anedoc@catholic.ac.kr

Abstract

BACKGROUND
The recovery time in propofol target controlled infusion (TCI) can be determined by the context sensitive decrement time (CSDT) using a Multichannel TCI system. Therefore, it is important to obtain the default CSDT in a Multichannel TCI system. The effect-site concentrations for eye opening and orientation in adults after propofol-remifentanil TCI were evaluated according to the CSDT using a Multichannel TCI system.
METHODS
After obtaining informed consent and Institutional Review Board approval, 135 ASA Class I or II patients scheduled to undergo elective surgery were divided into 3 groups according to age. The three groups included the following: group 1 (n = 45), 18-19 years; group 2 (n = 45), 30-39 years; and group 3 (n = 45), 40-54 years. The propofol infusion was started at a propofol target effect-site concentration (CeT) of 6microg/ml. Anesthesia was maintained primarily with a propofol CeT of 2.5microg/ml, a remifentanil CeT of 6ng/ml and with 67% nitrous oxide in oxygen. The average effect-site concentrations of propofol at eye opening and orientation in each group were estimated.
RESULTS
The average range of the effect-site concentrations of propofol at eye opening and orientation after surgery were 0.9-1.1microg/ml. The range of times to eye opening and orientation after stopping the nitrous oxide and infusion after surgery were 10.9-12.9 min.
CONCLUSIONS
The average range of the effect-site concentrations of propofol at eye opening and orientation after propofol-remifentanil TCI in Koreans are 0.9-1.1microg/ml.

Key Words: Intravenous anesthesia, Orientation, Propofol, Remifentanil