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Neuromuscular Physiology and Pharmacology
Anesthesia and Pain Medicine 2011;6(4):385-388.
Published online October 31, 2011.
Successful anesthetic management of two myasthenic patients using total intravenous anesthesia without muscle relaxants: A report of two cases
Jong Taek Park, Si gon Kim, Young bok Lee
Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Myasthenia gravis (MG) is an autoimmune-mediated disease characterized by weakness and fatigability due to dysfunction of the neuromuscular junction from antibodies directed against the acetylcholine receptor (AchR). The main considerations for the anesthesiologist are the underlying muscle weakness and interactions with various anesthetic drugs. This includes sensitivity to neuromuscular blocking agents and volatile agents, and the risk of postoperative respiratory failure. We report two cases of transsternal thymectomy for MG under general anesthesia with the use of a bispectral index-monitored total intravenous technique using propofol and remifentanil without muscle relaxants.
Key Words: Anesthetics, Muscle relaxant, Myasthenia gravis, Total intravenous anesthesia, Transsternal thymectomy

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