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Anesthetic Pharmacology
Anesthesia and Pain Medicine 2012;7(2):125-131.
Published online May 1, 2012.
The effects of sevoflurane and propofol-remifentanil on postoperative hepatic and renal function after laparoscopic and open abdominal surgeries
Won Ji Rhee, So Ron Choi, Ji Hyeon Lee, Sang Yoong Park, Ji Yeon Lee, Chan Jong Chung
Department of Anesthesiology and Pain Medicine, Dong-A University College of Medicine, Busan, Korea.
Sevoflurane and propofol-remifentanil have been known to cause less organ toxicities. However, there are few reports comparing the hepatic and renal effects of both anesthetic regimens. This study was intended to compare sevoflurane with propofol-remifentanil on postoperaitve hepatic and renal function in patients who underwent laparoscopic and open abdominal surgeries retrospectively.
Adult patients who had undergone abdominal surgeries were enrolled to conduct retrospective analyses. Total number of 717 patients was largely divided into a laparoscopic surgery (n = 309) and an open surgery (n = 408). The each of laparoscopic and open surgery was divided into a sevoflurane group (Group SEVO) and a propofol-remifentanil group (Group TIVA). Hepatic and renal markers were measured before the operation and on the first and second postoperative day.
Serial changes of postoperative hepatic and renal markers in the laparoscopic and open surgeries were shown in similar patterns between the Group SEVO and the Group TIVA. And there were no statistical differences in the incidence of clinically significant increases in serum SGOT, SGPT, and Cr.
As sevoflurane and propofol-remifentanil did not show influence on the hepatic and renal function, they may be used safely on patients undergoing the abdominal surgeries.
Key Words: Kidney function, Liver function, Propofol, Remifentanil, Sevoflurane

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