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Pediatric Anesthesia
Anesthesia and Pain Medicine 2012;7(3):203-209.
Published online July 31, 2012.
Target controlled infusion for total intravenous anesthesia in children
Hee Soo Kim
Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Korea.
Although the inhalational anesthesia is the most popular in children, sometimes intravenous anesthesia is inevitable when the patients are susceptible for malignant hyperthermia or need for intraoperative neurologic monitoring. At present there is not an appropriate pediatric pharmacokinetic and pharmacodynamic model for propofol and propofol is used by manual infusion by body weight, heart rate or blood pressure during anesthesia. Target controlled infusion (TCI) of propofol is the most popular method for administration of propofol in adults. Therefore it is necessary to develop a propofol model for TCI in children. Recently newly developed pediatric pharmacokinetic and pharmacodynamic model for propofol and it will be introduced to anesthesiologists.
Key Words: Children, Propofol, Target controlled infusion

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