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Neuromuscular Physiology and Pharmacology
Anesthesia and Pain Medicine 2012;7(4):352-354.
Published online October 31, 2012.
Anaphylaxis induced by priming dose of rocuronium during induction of anesthesia: Report of two cases
Young Woo Cho, Se Hun Park, Jin Gyu Jeong, Kang Il Kim, Hee Won Son
Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.
We experienced 2 cases of anaphylaxis during induction of anesthesia. Anesthesia was induced with a priming dose of rocuronium and followed by thiopental sodium two minutes later. Immediately after injection of thiopental sodium, they showed a sudden active coughing, urticaria around neck, and difficult ventilation. The residual intubating dose of rocuronium was injected to do endotracheal intubation. Subsequently, patients showed severe hypotension, hypoxia, and erythema. Rapid treatment was applied and they were recovered without any complications. The first patient had rejected skin test for drugs, but the second patient had a positive skin test for rocuronium two weeks after event.
Key Words: Anaphylaxis, General anesthesia, Priming, Rocuronium

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