Anesth Pain Med Search


Anesthetic Pharmacology
Anesthesia and Pain Medicine 2014;9(2):77-86.
Published online April 30, 2014.
Pharmacokinetic and pharmacodynamic modeling in anesthetic field
Dong Woo Han
Department of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Seoul, Korea.
Received: 8 January 2014
Models are simplified descriptions of true biological processes. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is a mathematical description on the relationship between pharmacokinetics and pharmacodynamics. The PK/PD modeling allows estimation of PK/PD parameters and it can establish dose-concentration-response relationships which describe and predict the effect-time courses of a drug. PK/PD modeling has recently emerged as a major tool in clinical pharmacology in order to optimize drug uses by designing rational dosage forms. Population analysis is used to estimate the variability in the population and also to establish guidelines for the individualization of drug dosage regimen. Non-linear mixed effect model is the basis of population approach. This approach permits the simultaneous analysis for all the data of the studied population, by using either PK or PD models to describe the typical trends (population means) and individual profiles. The target controlled infusion system is based on the population PK models which describe the inter-individual PK variability by individualizing the PK parameters according to the patient's covariate. The PK/PD modeling is highly useful for the development of drugs as well as for pharmacotherapy.
Key Words: Non-linear mixed effect model, Pharmacokinetic/pharmacodynamic model, Population analysis, Target controlled infusion
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 1,240 View
  • 42 Download
Related articles in Anesth Pain Med

Neuromuscular blockade and pharmacokinetic-pharmacodynamic modeling2009 October;4(4)

Article category

Browse all articles >


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail:                

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next