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Obstetric Anesthesia
Anesthesia and Pain Medicine 2014;9(2):128-133.
Published online April 30, 2014.
Effects of magnesium sulfate on the labor duration and neonatal outcome in parturients with preeclampsia
Eun Hee Chun, Sang Hwan Do, Hyun Jung Shin, Hyo Seok Na, Jung Won Hwang
1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
2Department of Anesthesiology and Pain Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Received: 26 February 2014   • Revised: 12 March 2014
Magnesium sulfate (MgSO4) is a drug of choice for women with preeclampsia, with evidence that it reduces progression to eclampsia and maternal mortality. However, no previous studies have been conducted on the effect of magnesium sulfate on labor. This retrospective study investigated the effect of magnesium sulfate on the labor duration and the neonatal outcomes in parturients with preeclampsia.
We reviewed the medical records of 209 women who delivered vaginally with the diagnosis of preeclampsia from January 1, 2003 to June 30, 2013. They were divided into two groups, primipara (Primi group) and multipara (Multi group). Then, each group was subclassified as MgSO4-treated (Mg group) and MgSO4-untreated group (Cont group) again. Collected data included the duration of each stage of labor and neonatal outcomes.
The duration of the 1st stage of labor was significantly longer in the Multi-Mg group, compared with the Multi-Cont group (138 +/- 149 min vs. 88 +/- 92 min, P = 0.025). However, the total labor durations were comparable between the two groups. Primi group had no difference in durations of any stage of labor and the total duration. Neonates showed worse outcomes (lower birth weight, lower Apgar, higher NICU admission rate) in the Primi-Mg group than the Primi-Cont group.
Although preeclamptic multiparous parturients treated with MgSO4 showed longer 1st stage of labor than those untreated with MgSO4, the total labor durations were comparable between the groups.
Key Words: Labor, Magnesium sulfate, Preeclampsia

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