Effectiveness of sugammadex in reversing prolonged neuromuscular block in a patient with acquired immune deficiency syndrome (AIDS) taking streptomycin: A case report

Kim, Jung Min; Kim, Kyo Sang; Koo, Min Seok

doi:2015.10.2.124

Anesth Pain Med > Volume 10(2); 2015 > Article

Case Report

Neuromuscular Physiology and Pharmacology

Anesthesia and Pain Medicine 2015;10(2):124-127.
DOI: https://doi.org/10.17085/apm.2015.10.2.124 Published online April 30, 2015.

Effectiveness of sugammadex in reversing prolonged neuromuscular block in a patient with acquired immune deficiency syndrome (AIDS) taking streptomycin: A case report

Jung Min Kim, Kyo Sang Kim, Min Seok Koo

¹Department of Anesthesiology and Pain Medicine, National Medical Center, Seoul, Korea. facharzt@gmail.com
²Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, Seoul, Korea.

Received: 5 December 2014 • Revised: 24 January 2015 • Accepted: 3 February 2015

Abstract

The duration of the effect of muscle relaxants is extended in patients with acquired immunodeficiency syndrome (AIDS); however, a specific mechanism for this effect has not yet been discovered. In addition, streptomycin is known to prolong the action of muscle relaxants by blocking activity at neuromuscular junctions. Here, we report the case of patient with AIDS taking streptomycin for pulmonary tuberculosis for which sugammadex was effective in reversing prolonged paralysis induced by rocuronium and vecuronium for video-assisted thoracoscopic surgery (VATS) lung wedge resection.

Key Words: AIDS, Aminoglycoside, Rocuronium, Sugammadex, Vecuronium