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Anesth Pain Med > Volume 10(4); 2015 > Article
Pediatric Anesthesia
Anesthesia and Pain Medicine 2015;10(4):284-287.
DOI:    Published online October 31, 2015.
Analysis of pre-operative aspartate aminotransferase and alanine aminotransferase in 14,185 pediatric patients
Kyung Cheon Lee, Su Jin Lee, Young Jin Chang, Yun Mi Kim, Hann Tchah
1Department of Anesthesiology and Pain Medicine, Gachon University Gil Medical Center, Incheon, Korea.
2Department of Nursing, Gachon University, Incheon, Korea.
3Deparment of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
Received: 9 March 2015   • Revised: 1 April 2015   • Accepted: 9 April 2015
The aim of this study was to investigate the efficacy of routine pre-anesthetic aspartate aminotransferase (AST) and alanine aminotransferase (ALT) tests for detection of hepatic abnormalities and usefulness in perioperative management.
The laboratory findings of 14,185 pediatric patients younger than 18 years from October 2004 to December 2010 were investigated by retrospective review of medical records. All of the patients had undergone preoperative AST and ALT screening.
Among the 14,185 patients, 221 patients experienced elevation of both AST and ALT. However, only 21 patients were suspicious for hepatic disease defined as persistent elevation of AST and ALT preoperatively. Among the 221 patients with elevation of both AST and ALT, 20 patients were examined by additional abdominal ultrasonography and hepatic abnormalities were detected in 13 of these patients (65%) and 40 patients were consulted to the department of pediatrics or internal medicine.
In this single-center, retrograde study, the usefulness of preoperative routine AST and ALT testing was shown to be limited for detection of hepatic abnormalities in pediatric patients undergoing general anesthesia. Further multi-center, large-scale investigation would be required.
Key Words: Alanine aminotransferase, Aspartate aminotransferase, Pediatrics, Pre-anesthetic

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