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Accuracy assessment of a PION TCI pump based on international standards
Anesth Pain Med 2019;14(4):407-11
Published online October 31, 2019
© 2019 Korean Society of Neuroscience in Anesthesiology and Critical Care.

Il Doh1 , Seok Hwan Lee2 , Yong-Hun Lee3 , Bokyoung Jeon3 , Byung-Moon Choi3 , and Gyu-Jeong Noh3,4
1Center for Medical Metrology, 2Center for Thermometry and Fluid Flow Metrology, Korea Research Institute of Standards and Science (KRISS), Daejeon, Departments of 3Anesthesiology and Pain Medicine, 4Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to: Byung-Moon Choi, M.D., Ph.D. Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: 82-2-3010-1704 Fax: 82-2-3010-6790 E-mail: byungmoonchoi7@gmail.com
ORCID https://orcid.org/0000-0002-6561-8851
Received March 19, 2019; Revised May 3, 2019; Accepted May 9, 2019.
cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Inaccuracies associated with target-controlled infusion (TCI) delivery systems are attributable to both software and hardware issues, as well as pharmacokinetic variability. However, little is known about the inaccuracy of the syringe pump operating in TCI mode. This study aimed to evaluate the accuracy of the TCI pump based on international standards.
Methods: A test apparatus for accuracy evaluation of a syringe pump (PION TCI®, Bionet Co. Ltd.) was designed to apply the gravimetric method. Pump accuracy was evaluated in terms of deviation defined by the following equation: infusion rate deviation (%) = (RatemeaRateest) / Rateest × 100, where Ratemea is the infusion rate (ml/h) as measured by the gravimetric system, and Rateest is the infusion rate (ml/h) as estimated by the pump. An infusion rate representing TCI mode was determined from previous clinical trial data which evaluated the predictive performance of the pharmacokinetic model. The PION TCI pump used in that clinical trial was used to evaluate accuracy of the syringe pump. The distribution of infusion rates obtained from the clinical trial was calculated, and the median value of the distribution was determined as the representative value.
Results: The representative infusion rate representing TCI mode was 31 ml/h, at which the infusion rate deviation was 4.5 ± 1.6%.
Conclusions: The inaccuracy of the syringe pump contributing to TCI system inaccuracy is insignificant.
Key Words : Accuracy; Infusion; Pump.


October 2019, 14 (4)
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