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Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after orthopedic surgery
Anesth Pain Med 2018;13(3):271-7
Published online July 31, 2018
© 2018 The Korean Society of Anesthesiologists.

Dong-won Lee, Jihyun An , Eunju Kim, Ji-hyang Lee, Hyun Kim, and Jong-chul Son
Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea
Correspondence to: Jihyun An, M.D. Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, 99 Ayang-ro, Dong-gu, Daegu 41199, Korea Tel: 82-53-940-0114 Fax: 82-53-954-7417 E-mail: ORCID
Received August 16, 2017; Revised November 20, 2017; Accepted November 20, 2017.
cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Oxycodone is widely used as bolus or patient-controlled analgesia (PCA) for control of postoperative pain. The aim of this study was to assess the efficacy and side effects of oxycodone for somatic pain by comparing oxycodone and fentanyl intravenous PCA after orthopedic surgery.
Methods: Seventy-three patients undergoing orthopedic surgery were randomly assigned to receive fentanyl or oxycodone using intravenous PCA (potency ratio 1:60). Pain severity at rest and with movement and adverse effects were assessed at 1, 6, 24, and 48 hours after surgery. The PCA dose and patient satisfaction scores were measured at 48 hours after surgery.
Results: The resting visual analogue scale (VAS) and moving VAS scores of the oxycodone group were significantly higher than those of the fentanyl group at 6 hours (P = 0.001, P = 0.021), but at 48 hours, the resting and moving VAS of the oxycodone group were significantly lower than those of the fentanyl group (P = 0.014, P = 0.037). There were no significant differences in adverse effects, satisfaction scores, dose of patient-controlled mode, or total cumulative PCA dose.
Conclusions: With a 1:60 ratio of oxycodone to fentanyl when using PCA for pain control after orthopedic surgery, the use of larger doses of oxycodone for 6 hours is effective in controlling early postoperative pain.
Key Words : Fentanyl, Othopedics, Oxycodone, Patient-controlled analgesia, Postoperative pain.

July 2018, 13 (3)
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