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Pre-anesthetic sedative effect of dexmedetomidine in laparoscopic cholecystectomy performed under general anesthesia
Anesth Pain Med 2018;13(1):23-9
Published online January 31, 2018
© 2018 Korean Society of Anesthesiologists.

Jae Won Kim1, Hye Lim Lee1, Joo Seung Park2, Ji Hoon Kim2, and Keon Hee Ryu1
Departments of 1Anesthesiology and Pain Medicine, 2Surgery, Eulji University Hospital, Daejeon, Korea
Correspondence to: Keon Hee Ryu, M.D., Ph.D.
Department of Anesthesiology and Pain Medicine, Eulji University Hospital, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Korea
Tel: 82-42-611-3655
Fax: 82-42-611-3882
Received April 6, 2017; Revised September 8, 2017; Accepted September 8, 2017.
cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: This study evaluated the effects of pre-anesthetic administration of dexmedetomidine on sedative, cardiovascular, and recovery parameters.
Methods: This was a prospective, randomized, double-blind, placebo-controlled study. We selected 60 patients who were scheduled to undergo laparoscopic cholecystectomy. They were randomly divided into two groups and received 0.5 µg/kg of dexmedetomidine (group D) or normal saline (group S) over 10 minutes before induction of anesthesia. The Ramsay sedation scale (RSS) score and bispectral index (BIS) were recorded after completion of the dexmedetomidine infusion. Mean arterial pressure (MAP), heart rate (HR), peripheral pulse oximetry, cardiac output (CO), and systemic vascular resistance (SVR) were recorded. The modified Aldrete recovery score (MARS) was recorded in the recovery room.
Results: After completion of the dexmedetomidine infusion, BIS reduction was less than 20% (97.1 ± 2.4, 83.8 ± 4.8; P < 0.001), but RSS-rated sedation was appropriate (P < 0.001). HR was lowest at the end of the dexmedetomidine infusion and there was a significant difference between groups (P < 0.001); however, MAP was not significantly different between groups (P = 0.139). CO was lowest and SVR was highest at the end of the dexmedetomidine infusion. There was no significant difference in MARS values between groups (P = 0.190).
Conclusions: A pre-anesthetic dexmedetomidine (0.5 µg/kg) provided appropriate sedation without serious changes in cardiovascular parameters or a prolonged recovery time.
Key Words : Dexmedetomidine, Laparoscopic cholecystectomy, Moderate sedation.

January 2018, 13 (1)
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