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Nefopam does not influence onset and recovery profiles of rocuronium-induced neuromuscular block: a prospective, double-blinded, randomized, controlled study
Anesth Pain Med 2018;13(3):286-91
Published online July 31, 2018
© 2018 The Korean Society of Anesthesiologists.

Keum Young So1,2, Hyun Mae Moon1, and Sang Hun Kim1,2
Department of Anesthesiology and Pain Medicine, 1Chosun University Hospital, 2Chosun University School of Medicine, Gwangju, Korea
Correspondence to: Sang Hun Kim, M.D., Ph.D. Department of Anesthesiology and Pain Medicine, Chosun University School of Medicine, 309 Pilmundaero, Dong-gu, Gwangju 61452, Korea Tel: 82-62-220-3223 Fax: 82-62-223-2333 E-mail: ksh3223@chosun.ac.kr ORCID http://orcid.org/0000-0003-3869-9470
Received December 26, 2017; Revised January 30, 2018; Accepted February 5, 2018.
cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: We investigated the hypothesis that pretreatment with nefopam 20 mg would influence the onset and recovery profiles of rocuronium-induced neuromuscular block.
Methods: After Institutional Review Board approval, 134 patients, aged between 20–65 years, belonging to the American Society of Anesthesiologists physical status classification I or II, were randomly allocated to receive either 0.9% normal saline (control group) or nefopam 20 mg (nefopam group), infused over one hour before induction of anesthesia. Anesthesia was induced with remifentanil and propofol, followed by endotracheal intubation with rocuronium 0.6 mg/kg. We recorded the lag time, onset time, clinical duration, recovery index, recovery time, and total recovery time.
Results: We included 111 patients in the final analysis. The lag time, onset time, clinical duration, recovery index, recovery time, and total recovery time of the nefopam group (n = 57) were not significantly different compared with that of the control group (n = 54).
Conclusions: Pretreatment with nefopam 20 mg one hour before induction of anesthesia does not have a significant influence on the onset and recovery profiles of rocuronium-induced neuromuscular block.
Key Words : Drug interactions, Nefopam, Neuromuscular monitoring, Neuromuscular nondepolarizing agents.


July 2018, 13 (3)
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