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Comparison of the efficacy of a combination of high dose metoclopramide and dexamethasone, with that of haloperidol, midazolam and dexamethasone, for the prevention of postoperative nausea and vomiting in laparoscopic gynecologic surgery
Anesth Pain Med 2018;13(3):278-85
Published online July 31, 2018
© 2018 The Korean Society of Anesthesiologists.

Young Seok Jee1, Hea-Jo Yoon2 , Yeon-soo Park2, and Dong woo Kim2
Department of Anesthesiology and Pain Medicine, 1Konyang University College of Medicine, Daejeon, 2Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea
Correspondence to: Hea-Jo Yoon, M.D. Department of Anesthesiology and Pain Medicine, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, 17 Seoae-ro 1-gil, Junggu, Seoul 04619, Korea Tel: 82-2-2000-7626 Fax: 82-2-2000-7785 E-mail: heajo7890@hanmail.net ORCID http://orcid.org/0000-0003-2180-4940
Received August 30, 2017; Revised January 4, 2018; Accepted January 12, 2018.
cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: This prospective randomized double-blinded study was designed to compare the efficacy of a combination of high dose metoclopramide and dexamethasone with that of haloperidol, midazolam and dexamethasone, for the prevention of postoperative nausea and vomiting (PONV) in patients scheduled for laparoscopic gynecologic surgery who are receiving fentanyl intravenous-patient controlled analgesia.
Methods: The subjects were randomly allocated to either group M (20 mg metoclopramide and 10 mg dexamethasone was administered at induction, n = 35) or group H (1 mg haloperidol, 3 mg midazolam and 10 mg dexamethasone were administered at induction, n = 35). The incidence of PONV and the severity (measured by numeric rating scale) of the patients’ nausea and pain were evaluated at 6 hours, 24 hours, and 48 hours, postoperatively.
Results: The overall incidence of the PONV was not significantly different between the two groups during the 48 hours period (group M: 21% vs. group H: 12%). The severity of the nausea and pain were similar between the two groups.
Conclusions: The prophylactic use of a combination of 1 mg haloperidol, 3 mg midazolam and 10 mg dexamethasone is as effective and inexpensive as 20 mg metoclopramide and 10 mg dexamethasone to prevent PONV.
Key Words : Dexamethasone, Haloperidol, Metoclopramide, Midazolam, Postoperative nausea and vomiting.


July 2018, 13 (3)
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